Shares moving sharply up or down in the pre-market include:

Genzyme (NASDAQ: GENZ), higher on news of a buyout by Sanofi-Aventis.

Dell (NASDAQ: DELL), up 7% after posting strong earnings

Borders Group down 25% after it declared bankruptcy.

Comcast (NASDAQ: CMCSA), up 3% on strong earnings.

American Capital (NASDAQ: ACAS) , up 6%, on better than expected numbers.

Photronics (NASDAQ: PLAB) pushing higher 9% on good earnings.

Fred’s (NASDAQ: FRED), higher by 7% on buyout rumors

Dollar Tree (NASDAQ: DLTR) on a buyout offer from Nelson Peltz

Douglas A. McIntyre