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At about mid-day, the Dow is off nearly -4%, the Nasdaq is off nearly -4.5%, and the S&P 500 is down just over -4%. It’s not a good day, and things are really looking nasty for several stocks. Here’s a look at some of today’s biggest losers so far.

NetApp Inc. (NASDAQ: NTAP) is down about -19% and has posted a new 52-week intra-day low of $33.32 following a poor earnings report, a weak forecast, and a downgrade from FBN. The stock is setting the pace for tech weakness after it pointed out that NetApp is expecting a “dramatic slowdown” in sales.

JDS Uniphase Corp. (NASDAQ: JDSU) is off -10.5%, at $10.47, within a 52-week range of $9.09-$29.12. The company managed to dodge a downgrade, but yesterday’s earnings and guidance combined with NetApp’s warning have clobbered the stock.

Invesco Mortgage Capital Inc. (NYSE: IVR) is off more than -8.5%, at $17.63, in a 52-week range of $16.48-$24.07. The company has announced a secondary offering of 20 million shares at $18.37/share, $0.92/share lower than yesterday’s closing price. Shareholders hate that sort of thing.

Citigroup Inc. (NYSE: C) shares are off around -7%, at $27.90, in a 52-week range of $26.25-$51.50. There’s no specific news that would lead to this drop, just the usual worries on European debt, home sales, and any of a number of economic concerns.

Camelot Information Systems Inc. (NYSE: CIS) is down more than -31%, at $5.87, having already posted a new 52-week low this morning of $4.90. That’s down nearly -80% from its 52-week high of $28.18. The company missed both profit and revenue estimates. There have also been some questions recently about the company’s truthfulness in reporting.

Gentium SpA (NASDAQ: GENT) is off more than -30%, at $6.12, within a 52-week range of $4.53-$13.69. The Italian drug maker has withdrawn a marketing application for an experimental treatment for complications resulting from stem cell transplants.

Acme Packet, Inc. (NASDAQ: APKT) is down nearly -18%, at $41.25, in a 52-week range of $30.70-$84.50. The communications equipment maker’s stock was downgraded by Pacific Crest, and is wallowing in the NetApp disaster.

Riverbed Technology Inc. (NASDAQ: RVBD) is down nearly -16%, at $20.53, in a 52-week range of $17.36-$44.70. Another communications equipment vendor and another downgrade at Pacific Crest.

The Direxion Daily Technology Bull 3X Shares (NYSE: TYH) is down nearly -16%, at $29.00, in a 52-week range of $23.66-$57.23. The triple-leveraged ETF is getting pulverized on its long technology bet.

MGM Resorts International (NYSE: MGM) is off -12%, at $10.15, in a 52-week range of $8.92-$16.94. Investor Kirk Kerkorian’s Tracinda Corp. reported yesterday that he has shed 20 million MGM shares. Tracinda is still the largest shareholder in MGM with nearly a stake of nearly 27% .

EMC Corp. (NYSE: EMC) is off more than -10%, at $20.22, in a 52-week range of $17.90-$28.73. The company is down about -24% in the past month, and today is following the downward spiral created by NetApp.

Bank of America Corp. (NYSE: BAC) is among the volume leaders with the largest share price downturns today. Shares are down nearly -7%, at $6.96, in a 52-week range of $6.31-$15.31. Worries about bank stocks are growing as reports on the global economy get gloomier.

Oracle Corp. (NASDAQ: ORCL) has already traded more shares than its daily average of more than 34 million. Shares are off nearly -8%, at $25.35, within a 52-week range of $21.66-$36.50. No particular news except the general disillusionment with tech stocks following NetApp’s pronouncement.

Paul Ausick