Markets were just below all-time highs over the course of the past week, until Friday when everything pulled back. Is this the end of the holding pattern? There are a fair number of questions for what the markets hold after this summer, but a somewhat negative analyst sentiment surrounds this movement.

As we have said before, some analysts believe that these highs are not fundamentally justified, and they might be right after Friday’s move.

The markets slumping to close out the week is the result of many different companies ruining shareholders. 24/7 Wall Street has picked out a few companies posting the largest losses for the week. We have included a note on why each stock has lagged, as well as a recent trading history, consensus analyst price target and a 52-week trading range.

Tonix Pharmaceuticals

On Tuesday, Tonix Pharmaceuticals Holding Corp. (NASDAQ: TNXP) was the disaster of the day after the company announced that it will stop development of its fibromyalgia treatment after it failed in a late-stage trial. While the drop might signal the beginning of the end here, there also might still be some hope for Tonix. The company did confirm that it will shift the focus of its TNX-102 SL toward patients suffering from post-traumatic stress disorder (PTSD). This represents a huge opportunity if successful, but investors need to understand that the prospects for upside hopes that were offered up even last month just became drastically reduced.

In the study, Tonix showed that the drug candidate did not meet its primary pain reduction target by 30% or more over a 12-week period. What is interesting is that this drug candidate has shown a stronger effect on PTSD patients than its efficacy in treating fibromyalgia. Management has even concluded that it might be able to secure a breakthrough therapy status.

Shares of Tonix closed the week out down 64% at $0.78. The stock has a consensus price target of $6.57 and a 52-week trading range of $0.76 to $7.95.

AMD

Shares of Advanced Micro Devices Inc. (NASDAQ: AMD) also were hit hard, down over 6%, after news late Tuesday that AMD is issuing just over $1 billion in new securities. The offering was listed as being $600 million in common stock and $450 million in convertible senior notes. On top of that, AMD granted the underwriters a 30-day overallotment option to purchase up to $90 million in shares and up to $67.5 million of the convertible senior notes. That makes the real potential offering $1.2 billion if the overallotment is taken.

AMD shares ended the week down 21.5% to $5.89, with a consensus price target of $5.94 and a 52-week range of $1.65 to $8.00.

Pier 1 Imports

When Pier 1 Imports Inc. (NYSE: PIR) gave a business update after the markets closed on Wednesday, it revised its preliminary results and guidance and announcing a transition in management. Anytime there is an update in either of these regards, we can expect the stock to be on the move shortly thereafter. In this case, when guidance is adjusted down and the chief executive officer of 10 years is leaving as well, we can expect the move to be a negative one.

In the release, the company detailed that preliminary net sales for the second quarter decreased by roughly 6.7% compared to the same period a year ago. E-commerce sales represented 20% of net sales in this time. Company comparable sales, which include e-commerce, decreased 4.3% year over year.

The second-quarter loss per share is expected to be in the range of $0.06 to $0.05, related to the planned departure of Pier 1’s CEO. Consensus estimates from Thomson Reuters call for a net loss of $0.03 per share and $422.19 million in revenue for the second quarter.

Pier 1 shares had a rocky road as well, with the stock down 15.8% for the week. Shares were last seen at $3.84, with a consensus price target of $5.41 and a 52-week range of $3.76 to $10.36.

HD Supply

Industrial distributor HD Supply Holdings Inc. (NYSE: HDS) reported second-quarter fiscal 2016 results before markets opened Wednesday. The company posted adjusted diluted earnings per share (EPS) of $0.85 and $2.02 billion in revenues. In the same period a year ago, the company reported adjusted EPS of $0.56 on revenue of $1.94 billion. Second-quarter results also compare to the Thomson Reuters consensus estimates for EPS of $0.88 and $2.03 billion in revenue.

The company modified its estimate for full-year sales growth in excess of estimated market growth from a previous estimate of 3% to a new estimate of flat to up 3%. For the third quarter, HD Supply expects revenues of $1.99 to $2.04 billion and adjusted EPS of $0.77 to $0.82. Analysts have a full-year EPS estimate of $2.72 and sales at $7.54 billion. For the third quarter, analysts are looking for EPS of $0.91 and revenues of $2.06 billion.

Shares most recently closed at $30.54. The consensus price target is $40.57, and the 52-week range is $21.26 to $36.99. Over the course of the past week, the stock was down 17%.

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Tractor Supply

The business update Tractor Supply Co. (NASDAQ: TSCO) provided on Wednesday unfortunately was brought about by market headwinds. Net sales for the third quarter are expected to increase approximately 4.2% to 5.0% to $1.54 billion to $1.55 billion from $1.48 billion in the third quarter of 2015, with comparable store sales ranging from flat to a decrease of 1.0%, versus an increase of 2.9% in last year’s third quarter. Comparable store transaction counts in the third quarter are expected to be slightly positive to flat in comparison to the prior year third quarter.

Consensus estimates call for $0.71 in EPS on $1.59 billion in revenue for the coming quarter.

Based on the company’s analysis of quarter-to-date results and trends, management currently believes the weaker-than-expected sales come from decreasing comps in energy producing regions, declining sales within communities dependent on the agricultural industry and lower demand for preseason heating related products.

Last week, the stock was down 19.6%. Shares closed out at $68.42 on Friday, with a consensus price target of $100.37 and a 52-week range of $68.13 to $97.25.

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