Posts for Ticker ‘BBH’

Biotech & BioHealth Business Daily (PFE, MRK, BAX, BDSI, SPPI, GNBT, AVII, CEGE, BBH, GILD, LLY, SNY, BMY, OSIP)

Here are some of today’s top stories affecting key drug and biotech stocks, accompanied with links through to more detailed information and analysis at BioHealthInvestor.com:

New short-interest data suggest traders are now increasing their directional bets against biotech stocks. Pfizer Inc. (NYSE: PFE) and Merck & Co. (NYSE: MRK) are in the top 10 of all large-cap stocks with the greatest increase in the number of shares shorted.

Eli Lilly has the FDA’s OK to market its Effient blood thinner, but the black-box warning on its label is so strong that it’s hard to believe it can dent the market share of the Sanofi Aventis (NYSE: SNY)/ Bristol Myers Inc. (NYSE: BMY) drug Plavix.

OSI Pharmaceuticals Inc. (Nasdaq: OSIP) announced new data from its Phase III Saturn study of Tarceva, and it’s likely an incremental positive for the cancer drug over rival Eli Lilly & Co.’s (NYSE: LLY) drug Altima.

-The 24/7 Wall St. Team

Biotech Movers & Shakers (AMGN, CRME, DNDN, GNVC, DNA, QLTI, TBRN, BBH, XBI)

Biotech’s are sliding along with all the others today. A look at the highlights and outliers:

Amgen (NASDAQ: AMGN) and Wyeth (NYSE: WYE) announced that arthritis and psoriasis drug Enbrel will now have a tuberculosis warning put on the label. Amgen down $1.27 to a nearly new low of $43.19 today with a 52 week range of $43.14 to $66.06. Wyeth shows less response–up $0.34 to $39.76, with a range of $39.50 to $62.30. 

Cardiome Pharma Corp. (NASDAQ: CRME) showed positive results in interim mid-stage data for abnormal heart rhythm drug. There is also talk of selling drug off. Shares responded with a 34% rise to $8.40 today. The 52 week range is $5.78 to $12.62. 

Dendreon (NASDAQ: DNDN) slipping after analysts question success of prostate-cancer vaccine Provenge clinical trial results that are due later this year. Down over 9% to $4.29 today.

GenVec (NASDAQ: GNVC) shares are still up after earnings call Friday. The company reported smaller than estimated losses despite a drop in revenue. The company projects higher revenues in 2008. Shares are up 5% to $1.24. The 52 week range is $0.97 to $4.72.

Genetech (NYSE: DNA) is still dipping after Friday’s earnings and projections for 2008 came up short to estimates. Down 2% to $77.15 today, the stock closed at $78.83 Friday. The 52 week range is $65.35 to $85.95.

QLT Inc. (NASDAQ: QLTI) up almost 50% on an FDA removal of blood screening and monitoring requirement for its acne treatment, Aczone. The FDA decision followed recent studies that resulted in no clinical evidence that anemia is associated with use of the drug. Shares are trading at $3.61 in early afternoon trading. The 52 week range is $2.43 to $8.40.

Trubion Pharmaceuticals (NASDAQ: TBRN) mysteriously up by 6% today. Last Thursday, the company reported widened losses, however, the losses weren’t as deep as estimated by Wall Street. Shares trading at $8.33 with a 52 week range of $5.84 to $22.46.

There is no easier way for basic investors to check how a sector is doing other than the ETF’s, and the Biotech ETF’s will describe the situation today.  The Biotech HOLDRs (AMEX: BBH) are down 2.6% at $166.05 today, and the SPDR Select S&P Biotech ETF (AMEX: XBI) is down almost 4% at $48.14.

Rachel Lopez
March 17, 2008

Can Genentech Buck Its Long-Term Slide? (DNA, BIIB, NVS, OSIP, AMGN, BBH)

Genentech (NYSE: DNA) is set to report earnings after the close today.  First Call has estimates pegged at $0.67 EPS on revenues of $2.97 Billion.  This will also mark the end of the fiscal 2007 and estimates there are $2.92 EPS on some $11.7 Billion in revenues.

If you were a biotech bull in 2003, 2004, and 2005 your favorite large cap biotech stock was probably Genentech (NYSE: DNA).  If you traded Genentech in 2006 and 2007, remaining a bull was one painful lesson.  In fact, shares very briefly hit $100 in December 2005 and they have recently traded as low as $65.60 this month.  Shares are down today by almost 1.5% at $70.45 but so far that $70 handle is holding.

Traditionally Genentech has remained a biotech that beats earnings expectations, although that number was only a "barely beat target" last quarter.  The problem that has persisted isn’t the actual growth as much as it is analysts and investors keying in on specific drug estimates not being a blowout on all of its labels.  Revenues were only $6.6 Billion for all of 2005.  The cancer franchise is massive there, yet there always seems to be a general disappointment in one drug or another  (Avastin, Rituxan, Herceptin, Lucentis, Xolair, Tarceva, Nutropin, Activase, Raptiva). 

What we are looking at now internally is the forward valuations, which we feel are achievable in light of the company having a multi-year plan in place.  With estimates showing Fiscal DEC-2008 at $3.37 EPS on revenues of $13 Billion, we have a forward P/E ratio of just under 21 for 2008, and a price to sales ratio (based on a $74 Billion market cap) of 5.69.  For what we believe is still the key leader in its cancer franchise with what is still believed to be a large drug candidate pipeline, we can easily live with these numbers.

Trying to use the "Value Investing" approach to biotech is not always applicable.  We’d merely point you to the woes at Amgen (NASDAQ:AMGN) and Biogen-Idec (NASDAQ:BIIB).  The forward P/E ratios and the sales multiples won’t matter at all if a blockbuster drug franchise comes under target.  While biotechs have been shielded in the past, it is open season on drugs during an election year whether you are a biotech company or just an old stodgy drug company.

We still believe that investors want to own stocks.  And as the economy slows into a recession we think investors will want to own stocks that may have implied safety nets in them.  Many of the other defensive stocks had been showing bubbly valuations just last week, and that doesn’t appear to be the case here.  Now we just have to see if the focus will turn back to the overall performance of the company as a whole.  If the focus will stay on each and every drug at the company then it’s hard to imagine that there won’t be any areas that traders can say were under their investment models.

Wall Street still has an average price target north of $82 per share over the next year and there is still a high target north of $100 out there.  The chart is still one that is at-risk longer-term, but on a short-term it has recovered.  If the street takes a disappointing reaction again we could see that going back to that $65.00 handle.  If there is some horrible unexpected news then who knows where they will find support as the year lows from December and January are roughly 30-month lows.  If options are any accurate tool today it appears that options traders are only looking at an expected price move of up to $2.50 or so in either direction.

As Genentech is the bogey in biotech now, it can affect the entire sector.  It also has partnerships with Novartis (NVS), Biogen-Idec (BIIB), OSI Pharma (OSIP), and others.  It is also still majority-owned by Roche, so the earnings implications and drug comments from Genentech can be far reaching and not just in the U.S.

Genentech is key to one ETF as it represents some 36% of the Biotech HOLDRs (AMEX:BBH). 

Jon C. Ogg
January 14, 2008

Biotechs and Related Hitting 52-Week Lows Too (BBH, AMGN, AMLN, ARNA, GERN, INGN, PGNX, SUPG)

Today has been a rough day with more 52-week lows than we can recall in quite some time.  The biotechs haven’t been immune.  You can even see that the Biotech HOLDRs (BBH) at $160+ are only about 2% above the 52-week lows of $157.95, while the iShares Nasdaq Biotechnology (IBB) ETF at $80.29 is only about half-way in its 52-week trading range of $72.37 to $89.00.  The difference is because of the composition.

Here are BIOTECH STOCKS hitting 52-week lows today:

  • Amgen (AMGN)
  • Amylin Pharma (AMLN)
  • Arena Pharma (ARNA)
  • Cleveland Biolabs (CBLI)
  • Geron (GERN)
  • Introgen (INGN)
  • Progenics Pharma (PGNX)
  • Somaxon Pharma (SOMX)
  • Spectrum Pharma (SPPI)
  • Supergen (SUPG)

If you wantto see how bad today is look at the master list of 52-week lows we compiled two hours ago with financials, restaurants, retail, REIT, property, tech and more.  It’s a huge list.

Jon C. Ogg
January 4, 2008