Posts for Ticker ‘ONXX’

Top Day Trader Alerts (BDK, DRIV, DNDN, DEPO, KBH, ONXX, V)

These are this morning’s top day trader and active alert stocks moving on volume.  We have provided links through to each stock with more detailed analysis and data at VSInvestor.com:

Black & Decker (NYSE: BDK) is running on significantly higher guidance.

Digital River, Inc. (NASDAQ: DRIV) is one of the biggest losers after Symantec is terminating a contract.

Dendreon Corporation (NASDAQ: DNDN) is surging over 5% on new solid board member additions to help it transition.

DepoMed, Inc. (NASDAQ: DEPO) is down over 30% after missing some hot flash trial endpoints.

KB Home (NYSE: KBH) is being hit by 5% on an SEC inquiry disclose.

ONYX Pharmaceuticals, Inc. (NASDAQ: ONXX) is trading up despite it acquiring a private company.

Visa Inc. (NYSE: V) is set to challenge 52-week highs on an upgrade.

You can join our open email distribution list to get updates each morning on analyst upgrades and downgrades, top day trader alerts, IPO’s and secondary offerings, Warren Buffett and other guru activity, M&A and more.

JON C. OGG

Top Day Trader Alerts (CIT, ONXX, HGSI, WINN, OFG, AAPL, AMD, YHOO, SBUX, AMLN, GILD)

The following are some of the top stocks to watch for active trading today based on pre-market and after-hours volume activity. There are links through to more detailed coverage and volume analysis at VSInvestor.com:

CIT Group Inc. shares (NYSE: CIT) are down on strong premarket volumes after Moody’s put some of its receivables-backed notes on review for a downgrade.

Onyx Pharmaceuticals Inc. (NASDAQ: ONXX) is up strongly on high volume after it and Bayer announced that a Phase 2 trial in advanced metastatic breast cancer met the primary endpoint.

Human Genome Sciences Inc. (Nasdaq: HGSI) are rising on a government order for its Abthrax product.

Winn-Dixie Stores Inc. (Nasdaq: WINN) shares are up strongly in the early going on its EBITDA guidance.

Oriental Financial Group Inc. (NYSE: OFG) shares are up strongly on earnings and investment portfolio gains.

Apple Inc. (Nasdaq: AAPL) is up strongly on an earnings beat, and slightly better-than-expected iPhone sales.

Advanced Micro Devices Inc. (NYSE: AMD) shares are down sharply, and among the most actives, following a wider-than-expected loss, and disappointing gross margins.

Yahoo Inc. (Nasdaq: YHOO) shares are down in the early going on disappointing  guidance and less-than-expected search revenue.

Starbucks Corp. (Nasdaq: SBUX) shares are up strongly following better-than-expected fiscal Q3 results and fiscal 2009 guidance.

Amylin Pharmaceuticals Inc. (Nasdaq: AMLN) shares are down on disappointing earnings.

Gilead Sciences Inc. (Nasdaq: GILD) shares are down, possibly after the company said U.S. wholesalers may decrease inventory levels of its HIV drugs.

-The 24/7 Wall St. Team

The Biotech Industry Prepares For A Wave Of Consolidation

biotech

Underscoring just how much big pharma will depend on biotech acquisitions for future revenue, an analysis published by Evaluate Pharma today suggests half of the top 100 drugs worldwide by 2014 – and all of the top six — will be biotechs.

Three in the top six – the anticancer drugs Avastin, Rituxan and Herceptin, — are all made by Roche, which recently moved to acquire even more biotech drugs with its plans to acquire Genentech. Read More »

Early Bird Analyst Upgrades & Downgrades (BLL, ONXX, RTP, TEF, ALV, ETEL)

These are some of the early bird analyst calls we are seeing from Wall Street analysts this Thursday morning:

  • Ball Corporation (NYSE: BLL) Raised to Buy at Citigroup.
  • Onyx Pharmaceuticals (NASDAQ: ONXX) Raised to Overweight at JPMorgan.
  • Rio Tinto (NYSE: RTP) Raised to Buy at Deutsche Bank.
  • Telefonica (NYSE: TEF) Raised to Outperform at Credit Suisse.
  • Autoliv (NYSE: ALV) Raised to Overweight at Morgan Stanley.
  • eTelecare Global Solutions (NASDAQ: ETEL) Cut to Neutral at Baird.

Jon C. Ogg
December 11, 2008

Select Positive ASCO Data (ARRY, AZN, LLY, DNA, GSK, ONXX, PFE, ZGEN)

Last night was a novel release from the American Society of Clinical Oncology (or ASCO) as the society decided to publish all of the findings to the public at once.  Keep in mind that many of the larger drug companies will have other presentations as well.  Below is some of the key and very brief data:

Array BioPharma (NASDAQ: ARRY) and AstraZeneca have announced plans for two additional randomized Phase II trials for AZD6244 in the second half of 2008 to test AZD6244 (ARRY-886) in combination with a chemotherapeutic agent; one trial will be for melanoma patients and the other for non-small cell lung cancer patients.  AstraZeneca (NYSE: AZN) showed positive breast cancer data in survivability.

Eli Lilly (NYSE: LLY) showed that its Alimta showed 3 months longer survival in a lung cancer sub-set group.

Genentech (NYSE: DNA) showed that Avastin in brain cancer trials showed 9 months survival while most patients live only 6 months from the study point.

GlaxoSmithKline (NYSE: GSK) showed that Tykerb added 1 year survival on advanced breast cancer patients.

Onyx Pharmaceuticals, Inc. (NASDAQ: ONXX) and Bayer HealthCare Pharmaceuticals announced that Nexavar tablets significantly improved overall survival by 47.3% in patients in the Asia-Pacific region with primary liver cancer versus those receiving placebo; Nexavar improved time to progression in these patients by 74%.

Pfizer (NYSE: PFE) presented data showing Celebrex may prevent lung cancer in current and former smokers.

ZymoGenetics, Inc. (NASDAQ: ZGEN) showed additional data from Phase 1 confirm that the combination is well-tolerated and shows anti-tumor activity; also reported positive results from the cohort expansion portion of a Phase 1 study with IL-21 and Rituxan in relapsed/refractory indolent lymphoma.

In the past investors had to wait for abstracts to be published and for presentations to be made.  It also was a situation where embargoes were used with media on releasing certain data.  Needless to say, there were many leaks on key data on who got what information when… and many profited from it.

This is only a brief summary of data from only a handful of the companies.  You can count on there being more data from many more biotech and drug companies… Floods of it.

Jon C. Ogg
May 16, 2008

Jon Ogg produces and edits the "10 Stocks Under $10" newsletter and he does not own securities in the companies he covers.

As Institutions Sell Millennium On Buyout News, Which Biotech Stocks Will See Inflows? (ALXN, CEPH, CBST, IMCL, ONXX, SEPR, UTHR)

The $8.8 Billion cash buyout of Millennium Pharmaceuticals, Inc. (NASDAQ: MLNM) has created a situation worth monitoring today.  It isn’t just that this buyout could create a cascade of other biotech deals.  The easier call is actually in just figuring out which emerging drug and biotech stocks will actually see new biotech investor inflows of cash from institutions that have to invest in these companies. More than 94% of MLNM was also listed as "held by institutions" according to data from Capital IQ.

Institutions have been selling the stock today from $24.30 to $24.50 rather than waiting for the $25.00 and this had traded more than 180 million shares late in the day (more than $4.3 Billion worth of stock).  As the institutions take this money out, that theoretically ends up in other similar criteria companies.  Of course this is only a very partial list, and we wouldn’t want to believe that those funds will only go into ‘identical criteria" emerging pharma and biotech stocks in the U.S. alone.  But here is a partial list of stocks that have somewhat similar characteristics that could be some of the beneficiaries in this scenario:

Alexion Pharmaceuticals, Inc. (NASDAQ: ALXN) with a $2.5 Billion market cap is now in its second transitionary year where revenues went from partnership and interest revenues into product revenues as analysts expect more than $213 million in 2008 revenues and more than $360 million for 2009.  Currently markets Soliris for blood disorders.

Cephalon, Inc. (NASDAQ: CEPH) has a $4.4 Billion market cap and established revenues of $1.77 Billion last year.  Analysts expect revenues to be $1.88 Billion this year and more than $2.1 Billion next year.  It already has drugs in place or in development for central nervous system disorders, pain, oncology, and addiction.

Cubist Pharmaceuticals Inc. (NASDAQ: CBST) may be a tad small with a $1.1 Billion market cap and with fresh contamination problems, but its name wasn’t left off.  2007 saw $294+ million in revenues, and analysts are looking for revenues of $391 million this year and $479 million next year.  Company’s Cubicin is on market as the first antibiotic in a new class of anti-infectives called lipopeptides for strep, staph, and other infections.

Imclone Systems (NASDAQ: IMCL) would have matched with a $3.8 Billion market cap and Erbitux as a current cancer drug, although this has been between $30 and $45.00 per share since its huge drop in 2004 and activists haven’t been able to make it budge.

Onyx Pharmaceuticals Inc. (ONXX) has a $1.9 Billion market cap and it has also transitioned to a revenue generator with analysts expecting revenues of $80 million this year and $161 million next year.  Nexavar is its kidney cancer and tumor drug, plus other partner studies in place.

Sepracor Inc. (NASDAQ: SEPR) has a $2.4 Billion market cap and is also in the revenue generation stage, although it has been a painful stock for many investors over the last 12 to 18 months.  Revenues are already established and analysts expect revenues to be $1.35 Billion this year and $1.53 Billion next year.  LUNESTA is major product, has key partners in place. 

United Therapeutics Corp. (NASDAQ: UTHR) has a market cap of $1.9 Billion and generated almost $211 million in 2007 revenues.  Analysts expect revenues to hit $261+ million this year and $346+ million next year.  Drugs treat cardiovascular, cancer, and infectious diseases.

You can join our open email distribution list to hear about special financings, secondary offerings, IPO’s, M&A, and more previews for other special situations in various stages.

Jon C. Ogg
April 10, 2008

Jon Ogg produces the Special Situation Investing Newsletter.  He can be reached at jonogg@247wallst.com and he does not own securities in the companies he covers.

Biotech Busine$$ Daily (AMLN, BIIB, CEPH, CYTK, ONXX, REGN, THRX, CBM)

Many biotech stocks are enjoying large gains Monday, although some are on no real breaking news. Here is a look at some notable gainers:

  • Amylin Pharmaceuticals Inc. (NASDAQ: AMLN) up $1.39 to $28.97, a 5% increase. The 52-week range is $23.75 to $53.25.
  • Biogen Idec Inc. (NASDAQ: BIIB) up nearly $3.00, a 5% increase to $61.94. Carl Icahn on CNBC said today he is going to stay after the company.  The 52-week range is $43.43 to $84.75.
  • Cephalon Inc.  (NASDAQ: CEPH) up a modest 1% to $65.35. Last Thursday, they received FDA approval for Treanda, a treatment for chronic lymphocytic leukemia. The 52-week high is $84.83.
  • Cytokinetics, Incorporated (NASDAQ: CYTK) up over 2% to $3.49. Today the company announced positive results from Phase IIa trials of cardiac myosin activator drug CK-1827452 for patients with stable heart failure.
  • Onyx Pharmaceuticals (NASDAQ: ONXX) up $1.94 to $29.36, over 7% up. The 52-week range is $23.73 to $61.18
  • Regeneron Pharmaceuticals (NASDAQ: REGN) up $2.21 to $19.86, a 12% increase on the day. The 52-week range is $13.55 to $28.74
  • Theravance Inc. (NASDAQ: THRX) up $1.13 to $10.53, a 12% jump. The 52-week range is $9.37 to $36.98.

One biotech stock that isn’t enjoying the upswing is Cambrex Corp. (NYSE: CBM). The company hit a new low, down over 13% to $6.95 on news that UCB Groups Parkinson’s treatment, Neupro, is being recalled. Neupro uses their ingredient and the recall should impact earnings. First Analyis Sec downgraded the stock today.

Rachel Lopez
March 24, 2008

Major Biotech Movers (AGEN, CEGE, ENCY, IDMI, IMCL, ONXX, PFE, NTII, OXGN, PSDV, SIRT)

Antigenics Inc.  (NASDAQ: AGEN) A study for Cancer vaccine, Oncophage, for the treatment of metastatic melanoma showed mixed results this morning. Shares are down almost 7% to $2.17. The 52 week range is $1.54 to $5.42.

Cell Genesys, Inc. (NASDAQ: CEGE). Shares continue to climb following report Friday citing that vaccine candidate GCAX showed immune response in prostate cancer patients. Shares are trading at $2.93 in mid-day trading. The 52 week range is $1.78 to $7.30.

IDM Pharma, Inc. (NASDAQ: IDMI). Downgraded by Rodman & Renshaw. Shares plummet over 18% to $2.57. The 52 week range is $0.57 to $10.75.

Imclone Pharmaceuticals (NASDAQ: IMCL). Halted testing for competitor Onyx Pharmaceuticals (NASDAQ: ONXX) in the lung cancer drug market and a 4.96% stake purchase by Steve Cohen’s hedge fund, SAC Capital, pushed Imclone up early Tuesday. Shares have returned down to $38.41 in mid-day trading. The 52 week range is $27.50 to $47.94

Neurobiological Technologies Inc. (NASDAQ: NTII) Received a $2.1 million quarterly royalty payment for sales of Memantine, a moderate-to-severe Alzheimer’s disease treatment, from Merz Pharmaceuticals GmbH. Shares have showed little reaction, trading at $2.67. The 52 week range is $2.06 to $19.53.

Oxigene Inc. (NASDAQ: OXGN) Secures $40 million committed equity financing facility. Shares are down over 3% and trading in at $2.05 with a 52 week range of $2.01 to $5.12.

Onyx Pharmaceuticals (NASDAQ: ONXX). Shares are down by $3.47 to $29.62, a 10% drop after being murdered yesterday due to a Phase III testing halt for its lung cancer drug Nexavar. Shares fell almost 25% yesterday. The 52 week range is $23.65 to $61.18.

Today, Pfizer (NYSE: PFE) announced offer to buy all issued and outstanding shares of Encysive Pharmaceuticals (NASDAQ: ENCY) for $2.35 per share, a transaction valued at $195 million in equity. Pfizer will acquire the rights to THELIN, a treatment for PAH currently in pre-Phase III clinical testing in the United States. Pfizer is up almost $0.10 to $22.45 in mid-day trading. The range is $21.56 to $27.73. Encysive is up 110% to $2.27. The 52 week range is $0.59 to $5.02.

Psivida Ltd.  (NASDAQ: PSDV)  Received first R&D payments from Pfizer of $500,000 in part of an over $160 million agreement. Shares are down over 2% at $0.78. The 52 week range is $0.39 to $2.99.

Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT). Co-founder to present first In-Vivo, pre-clinical data showing SIRT1 activation has the ability to suppress tumor formation in cancer of the intestine and colon. Shares are down trading at $11.59 with a 52 week range of $9.81 to $21.99.

Rachel Lopez
February 20, 2008

TOP 10 Pre-Market Analyst Calls (CBEY, DHT, GM, IACI, LVLT, NOV, ONXX, PDCO, TWTC, TIVO)

These are not the only analyst calls that are impacting key shares today, but these are the top ten that 24/7 Wall St. is looking at as impact events on their own:

Cbeyond Communications (CBEY) started as By at Citigroup.
Double Hull Tankers (DHT) raised to Buy at UBS.
General Motors (GM) raised to Peer Perform at Bear Stearns.
IAC/Interactive (IACI) raised to Buy at Piper Jaffray.
Level 3 (LVLT) started as Hold at Citigroup.
National Oilwell Varco (NOV) raised to Buy at Citigroup.
Onyx Pharmaceuticals (ONXX) started as Neutral at Goldman Sachs.
Patterson Co’s (PDCO) raised to Overweight at Lehman.
Time Warner Telecom (TWTC) started as Buy at Citigroup.
TiVo (TIVO) raised to Overweight from underweight at JPMorgan.

Jon C. Ogg
November 29, 2007

Pre-Market Analyst Calls (October 2, 2007)

ACAD started as Hold at Citigroup.
ALB raised to Neutral at Goldman Sachs.
AMB raised to Buy at B of A.
APD cut to Neutral at Goldman Sachs.
BAC started as Buy at Goldman Sachs.
BDN cut to Neutral at B of A.
BIIB cut to Underperform at Credit Suisse.
BRLC cut to Neutral at R.W.Baird.
CBS cut to Hold at Deutsche Bank.
CNH cut to Neutral at Goldman Sachs.
CYPB started as Outperform at FBR.
ELN started as Underperform at FBR.
FRX raised to Hold at Citigroup.
MDCO raised to Buy at UBS.
MON removed from Goldman Sachs Conviction Buy List.
MPG cut to Sell at B of A.
NOK cut to Mkt Perform at JMP Securities.
NVT raised to Hold at Deutsche Bank (ooops); cut to Neutral at UBS.
ONXX cut to Peer Perform at at Bear Stearns.
PDLI raised to Outperform at Wachovia.
PLD raised to Buy at B of A.
RATE cut to Neutral at Merriman Curhan Ford.
SLG cut to Neutral at B of A.
STEI started as Buy at B of A.
UBS raised to Neutral at JPMorgan.
VAL cut to Sell at Goldman Sachs.
WAG cut to Neutral at Goldman Sachs (late Monday call); cut to Neutral at Merrill Lynch.

Jon C. Ogg
October 2, 2007

Cramer’s ASCO Biotech Stocks (CELG, ONXX, WMT)

On today’s Stop Trading segment on CNBC, Jim Cramer said he was shocked that Revlimid from Celgene (CELG) was hardly noticed and he thinks it’s ready to run here.  This down move in Celgene is a mistake.  He’s sticking with his Onyx Pharmaceuticals Inc. (ONXX) after they gave positive data at the American Society of Clinical Onclogy ("ASCO") after the company extended the life of liver cancer patients. 

Cramer said he’d still buy Wal-Mart (WMT-NYSE) here even after the run from the news Friday and after the upgrades today. 

Jon C. Ogg
June 4, 2007

Jon Ogg can be reached at jonogg@247wallst.com; he does not own securities in the companies he covers.

Cramer’s Three Biotech Picks, And His Biotech Strategy

Stock Tickers: DNA, AMGN, NFLD, CELG, GILD, GENZ, ONXX, DNDN

Jim Cramer has a video on TheStreet.com "Wall St. Confidential" showing how the biotech sector can be looked at with blow-ups.  For every small biotech that grown up into a huge company there are 100 Northfield Labs (NFLD).  Cramer thinks you have to play momentum and even stocks like Genentech (DNA) and Amgen (AMGN) have to be gotten out when they are no longer going up.

Cramer still likes Celgene (CELG), Gilead (GILD) and Genzyme (GENZ) in the sectore.  If you bet on one product wonders then have you to be prepared to lose everything.  Onyx Pharma (ONXX) is a potential one-hit wonder that Cramer likes, but says to play it you should buy deep in the money calls because any bad news could chop the stock in half.  He also noted that he believes the FDA is not predictable on upcoming drugs.

From an outsider’s view, it really looks like Cramer has been changing his stance more and more on biotechs.  It is obvious there have been blow-ups like Northfield and there have been fortunes made and lost in Dendreon (DNDN).  Cramer watchers will recall that he rode Amgen (AMGN) down day after day thinking it had bottomed, and stayed positive on Genentech (DNA) as the "winner"  while the stock itself has spent the better part of eighteen months rapidly going nowhere.

Jon C. Ogg
May 29, 2007

Jon Ogg can be reached at jonogg@247wallst.com; he does not own securities in the companies he covers.