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June 6, 2016: Here are four stocks trading with relatively heavy volume among 16 equities making new 52-week lows in Monday’s session. NYSE advancers led decliners by more than 2 to 1 while Nasdaq advancers led decliners by the same margin.

ProNAi Therapeutics Inc. (NASDAQ: DNAI) posted a new 52-week low on Monday. Shares traded at a low of $2.09, down about 67%, after closing at $6.38 on Friday. The stock’s 52-week high is $33.75. Volume was more than 5 times the daily average of 190,000 shares. The drug maker this morning reported poor results of a cancer drug trial.

Signet Jewelers Ltd. (NYSE: SIG) dropped by about 4.4% on Monday to post a new 52-week low at $84.27 after closing at $88.19 on Friday. The stock’s 52-week high is $152.27. Daily volume totaled more than 2 times the average of around 3.7 million shares. The company had no specific news Monday, but has not recovered from some bad news coverage last week.

Mirati Therapeutics Inc. (NASDAQ: MRTX) dropped nearly 46% on Monday to post a new 52-week low of $9.95 against a 52-week high of $52.00. The stock closed at $18.35 on Friday night. Volume was nearly 15 times the stock’s daily average volume of around 180,000 shares. Another drugmaker with weak trial results.

SeaWorld Entertainment Inc. (NYSE: SEAS) fell about 2.4% on Monday to post a new 52-week low of $16.42 against a high of $21.85. The stock closed at $16.83 on Friday night. Volume was nearly double the stock’s daily average of around 1.6 million. The theme parks operator had a tough May and June is not showing any big turnaround.