1. Walker County, Alabama
> Annual drug deaths per 100,000 residents: 47.5 (county) 16.0 (state)
> Drug-related deaths, 2012-16: 160 (county) 3,113 (state)
> Poverty rate: 21.9%
> Population 65,593

2. Anchorage Borough, Alaska
> Annual drug deaths per 100,000 residents: 18.2 (county) 17.0 (state)
> Drug-related deaths, 2012-16: 261 (county) 502 (state)
> Poverty rate: 8.1%
> Population 299,321

3. Mohave County, Arizona
> Annual drug deaths per 100,000 residents: 24.2 (county) 20.0 (state)
> Drug-related deaths, 2012-16: 243 (county) 5,429 (state)
> Poverty rate: 19.3%
> Population 203,629

4. Crawford County, Arkansas
> Annual drug deaths per 100,000 residents: 25.4 (county) 13.2 (state)
> Drug-related deaths, 2012-16: 78 (county) 1,568 (state)
> Poverty rate: 18.8%
> Population 61,927

5. Lake County, California
> Annual drug deaths per 100,000 residents: 43.2 (county) 12.7 (state)
> Drug-related deaths, 2012-16: 139 (county) 19,682 (state)
> Poverty rate: 24.6%
> Population 64,076