A 2015 study published in Annals of Internal Medicine found higher rates of type 2 diabetes in sedentary people. The exact connection between the two is not clear to doctors, but one theory is that sitting too much can affect sugar levels and fat metabolism negatively. Some doctors recommend that people in general stand up for about two minutes every 20 minutes or so to stretch and move around.
We are using a lot less energy when we sit than when we move or even stand, and this can lead to weight gain. Many studies have established a connection between obesity and sedentary lifestyle, mostly sitting and watching TV. The more time adults spend in front of a TV, the more likely they are to become overweight or obese. One study found that for every two hours women spent watching TV daily, they had a 23% higher risk of becoming obese and a 14% higher risk of developing diabetes.