Special Report

25 Most Dangerous Drugs

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The opioid epidemic is an ever-growing struggle: nearly 70,000 Americans died from a drug overdose last year, according to data released by the U.S. Centers for Disease Control and Prevention. While prescription painkillers and other street and illicit drugs have certainly fueled the rise in opioid deaths, they are not the only dangerous drugs. Many other drugs, including some seemingly-innocuous over-the-counter medications, can be dangerous. The opioid epidemic is on this list of the most serious public health issues facing America today.

Drug overdoses are now the leading cause of accidental death in the United States. More Americans die of drug overdoses than in car accidents, which are also frequently the result of substance abuse — nearly half of fatal car accidents involve alcohol or other substances.
To better understand the likelihood of Americans dying from using a specific substance, it is important to also get a better understanding of the substance itself — its properties, interactions with other drugs and alcohol, and how often it is used.

The vast majority of people who drink alcohol in the United States — more than half of Americans — do so responsibly. Millions of people also use pain medication every day and do not stray from their prescribed dosage. And while overdoses from prescription opioids are a major factor in the opioid epidemic, opioids are essential to many Americans who rely on them to function.

The double-edged sword of risk and reward in prescribing opiates is common to many other drugs as well. Approximately half of all people in the United States use at least one prescription drug on a regular basis.

24/7 Wall St. reviewed 25 of the most dangerous drugs and drug mixtures based on side effects and death rates tracked by the federal government, as well as potential risk of drug combinations measured by medical information organizations and web sources such as MedScape, WebMD, and the American Medical Association. These substances span well-known controlled substances, infamous street drugs produced in unsafe conditions, and lethal combinations of otherwise safe medications. Many of these drugs, when taken on their own and under the correct conditions, are considered to be generally safe. They are only seriously deadly when combined inappropriately with other drugs.

However, no drug is perfectly safe, and some widely-prescribed and popular over-the-counter medications are more likely to pose a risk to more Americans than rare drugs with a higher rates of dangerous side effects simply because they are more accessible. Some of the drugs on this list are a broad category of medication with similar effects and risks, while others are a single formula. According to doctors, opioids are not the only known effective pain treatment. Here is a list of nine non-opioid treatments approved by physicians.

Click here to see the 25 most dangerous drugs
Click here to read our detailed findings and methodology

Source: Michelle Tribe / Wikimedia Commons

1. Acetaminophen
> Common names/types: Tylenol, Mapap, Feverall
> Common uses: Pain relief
> Deadly when: Taken in excess, combined with alcohol, other pain meds containing acetaminophen
> Risks: Long-term liver damage, liver toxicity, death

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Source: David Shankbone / Wikimedia Commons

2. Alcohol
> Common names/types: Beer, wine, liquor
> Common uses: Recreation
> Deadly when: Combined with benzodiazepines, many other drugs
> Risks: Liver damage and failure, high blood pressure, death due to impaired motor functions

Source: Gotgot44 / Wikimedia Commons

3. Anti-Anxiety Medication (benzodiazepines)
> Common names/types: Xanax, Valium, Klonopin
> Common uses: Anxiety treatment
> Deadly when: Combined with barbiturates, opioids, or alcohol
> Risks: Overdose, dementia

Source: Gonegonegone / Wikimedia Commons

4. Anticoagulants
> Common names/types: Warfarin, Xarelto, Heparin
> Common uses: Blood clot risk
> Deadly when: Combined with Aspirin and other blood-thinning drugs
> Risks: Internal and external bleeding

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Source: Ragesoss / Wikimedia Commons

5. Antidepressants (SSRIs)
> Common names/types: Prozac, Lexapro, Paxil, Zoloft
> Common uses: Treatment of depression
> Deadly when: Other drugs that affect serotonin levels, opioids, NSAIDs
> Risks: Serotonin syndrome, suicide, internal bleeding

Source: MIND_AND_I / iStock

6. Anti-hypertensive Drugs
> Common names/types: Hytrin, Cardura, Minipress
> Common uses: High blood pressure
> Deadly when: Combined with NSAIDs and diuretics
> Risks: High blood pressure, acute renal failure, cerebrovascular complications

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Source: Maya23K / iStock

7. Bromocriptine
> Common names/types: Parlodel, Cycloset
> Common uses: Tumors, Parkinson’s disease, type 2 diabetes
> Deadly when: Combined with pseudoephedrine (Sudafed)
> Risks: Bleeding in the stomach, seizures, death

Source: Tijana87 / iStock

8. Clarithromycin
> Common names/types: Clarithromycin
> Common uses: Antibiotic
> Deadly when: Combined with calcium channel blockers, statins like Lipitor
> Risks: Fatal heart complications

Source: KatarzynaBialasiewicz / iStock

9. Clozapine
> Common names/types: Clozaril
> Common uses: Schizophrenia
> Deadly when: Combined with alcohol
> Risks: gastrointestinal hypomotility

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Source: andriano_cz / iStock

10. Cocaine
> Common names/types: Crack, coke, blow
> Common uses: Recreational stimulant, numbing agent
> Deadly when: Taken in excess, combined with heroin and opiates
> Risks: Death, heart attack, increased blood pressure

Source: Eversame / Wikimedia Commons

11. Colchicine
> Common names/types: Colcrys, Mitigare
> Common uses: Gout
> Deadly when: Combined with strong CYP3A4 Inhibitors
> Risks: Colchicine toxicity leading to death

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Source: Antonio_Diaz / iStock

12. Cough Medicine
> Common names/types: NyQuil, Robitussin, Theraflu
> Common uses: Cough
> Deadly when: Combined with antihistamines
> Risks: Amplified sedative state leading to accidents

Source: Wellcome Images / Wikimedia Commons

13. Digoxin
> Common names/types: Lanoxin
> Common uses: Heart conditions
> Deadly when: Combined with Quinidine
> Risks: Nausea, vomiting, death

Source: Kenishirotie / iStock

14. Heroin and Semi-synthetic Opioids
> Common names/types: Percocet, Vicodin, Oxycontin
> Common uses: Pain relief
> Deadly when: Taken in excess, combined with cocaine and other drugs
> Risks: Accidental overdose

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Source: Drug Enforcement Administration

15. MDMA
> Common names/types: Ecstasy
> Common uses: Recreational euphoria
> Deadly when: Taken in excess, combined with alcohol, SSRIs
> Risks: Serotonin syndrome, shock, coma, death

Source: Psychonaught / Wikimedia Commons

16. Methamphetamine
> Common names/types: Crystal meth, Desoxyn
> Common uses: Stimulant
> Deadly when: Accidental overdose
> Risks: Teeth loss, brain damage, death

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Source: U.S. Food and Drug Administration

17. Methotrexate
> Common names/types: Trexall, Rasuvo, Otrexup
> Common uses: Cancer, psoriasis, rheumatoid arthritis
> Deadly when: Taken too frequently, combined with Probenecid
> Risks: Liver, lung, or kidney damage, death

Source: Mike Mozart / Flickr

18. NSAIDs
> Common names/types: Advil, Aspirin, Ibuprofen
> Common uses: Pain relief, inflammation
> Deadly when: Combined with other blood-thinners
> Risks: Heart attack, stroke, Reye syndrome

Source: callum redgrave-close / iStock

19. Selective Serotonin Reuptake Inhibitors
> Common names/types: Celexa, Zoloft, Prozac, Lexapro
> Common uses: Depression
> Deadly when: Combined with other drugs that affect Serotonin levels
> Risks: Serotonin syndrome, increased risk of suicide

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Source: spflaum1 / iStock

20. Sildenafil
> Common names/types: Viagra, Revatio
> Common uses: Erectile dysfunction
> Deadly when: Combined with isosorbide mononitrate
> Risks: Death, dramatic blood pressure drop

Source: Sasha_Suzi / Flickr

21. Spironolactone
> Common names/types: Aldactone, CaroSpir
> Common uses: High blood pressure
> Deadly when: Combined with Potassium chloride
> Risks: hyperkalemia

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Source: rogerashford / iStock

22. Statins
> Common names/types: Lipitor, Lescol, Crestor
> Common uses: Heart disease
> Deadly when: Combined with Fluconazole
> Risks: muscle weakness and kidney damage or failure,

Source: Charles Wollertz / iStock

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