
Source: Fausto Zonaro / Wikimedia Commons
5. Byzantine-Ottoman War
> Duration: 1265-1479 (214 years)
> Combatants: Byzantine Empire and the Ottoman Empire
> Killed: unknown
> Fought in: Modern-day Turkey, western Asia Minor
The Byzantine-Ottoman Wars marked the end of the Byzantine Empire, as well as the Middle Ages of Europe. The Ottoman Empire continued to grow during the 13th, 14th, and 15th centuries, while the Byzantine-controlled territory shrank. Ottoman ruler Mehmed II dealt a crushing blow to the Byzantines with the Fall of Constantinople, when he seized the heavily fortified city.

Source: Jean Colombe - Adam Bishop / Wikimedia Commons /Public Domain
4. Byzantine-Seljuq War
> Duration: 1048-1308 (260 years)
> Combatants: Byzantine Empire and the Seljuk Turks
> Killed: unknown
> Fought in: Asia Minor and Syria
The Byzantine Empire was involved in more than two centuries-long conflicts, the longest being the war with the Seljuk Turks. For 260 years, the Byzantines and Seljuks lost and retook territory in Asia Minor and the surrounding areas. Though the Seljuk Turks lost some of their gained territory as a result of the Crusades, the Byzantine Empire was overstretched by the conflicts and could not maintain its territory. The war ended after 260 years and hastened the decline of the Byzantine Empire.

Source: Public Domain / Wikimedia Commons
3. Arauco War
> Duration: 1536-1825 (289 years)
> Combatants: The Araucanian Indians of Chile and the Spanish Empire
> Killed: unknown
> Fought in: Modern-day Chile, southern part of South America
For almost 300 years, the Spanish tried and failed to colonize the Araucanian people, which included the Mapuche, the Picunche, and the Huilliche, of modern day Chile. Though the Spanish conquistadors came to control much of South America, the Mapuche resisted, largely thanks to the natural border of the Bio Bio River. Spain declared peace with Chile and its inhabitants, including the Mapuche, in 1825 and Chile became independent.
2. Persian-Roman Wars
> Duration: 92 B.C.-A.D. 629 (721 years)
> Combatants: Roman Republic/Empire and the Parthians and the Sassanids in Persia
> Killed: unknown
> Fought in: Modern-day Iran
The Persian-Roman Wars went on for so long, they spanned two different Persian empires, the Parthians and the Sassanids. For much of the conflict, cities around the border were taken by one side, then recaptured by the other over and over again, without deep forays into enemy territory. Much of the damage was financial. Both sides spent so much preparing to fight each other they were left vulnerable to other attackers.

Source: Alfonso X / Wikimedia Commons
1. Iberian Religious War
> Duration: 711-1492 (781 years)
> Combatants: Spanish Empire and the Moors
> Killed: 7 million
> Fought in: Spain
The longest continual war in history was the Iberian Religious War, between the Catholic Spanish Empire and the Moors living in what is today Morocco and Algeria. The conflict, known as the “Reconquista,” spanned 781 years — more than three times as long as the United States has existed. As the Moors crossed the Meditterranean Sea and claimed territory in Europe, Spain was uncomfortable with encroachment by non-Christians and met the Moors in battle. Though it was not part of the Crusades, the war was supported by the Catholic Church. In the 15th century, Moorish power and territory waned. In 1492, the Spanish recaptured Grenada and cemented their status in the region, ending the Reconquista.
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