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The stock market is up Tuesday, with the Dow Jones Industrial Average up 0.43%, the Nasdaq up 0.81%, and the S&P 500 up 0.62%. Today’s winners include a pharmaceutical company reporting a good trial and a radio ratings service getting bought out. Today’s losers include a pharmaceutical selling stock to the public, a technology manufacturer warning of a fourth-quarter loss and a gun manufacturer whose investors are concerned about new regulations.

These are Tuesday’s market winners and losers.

Biggest Winners

Shares of Vanda Pharmaceuticals, Inc. (NASDAQ: VNDA) are up 23.91% to $3.99 on trading volume of 2.8 million shares. The company reported strong results for Tasimelton, a drug that helps treat a blindness condition known as non-24-hour disorder. The 52-week high is $5.47.

Shares of Arbitron Inc. (NYSE: ARB) are up 23.61% to $47.02 on trading volume of 12.1 million shares. Nielsen is planning to buy the radio ratings service for $48 a share, or about $1.26 billion. Before Tuesday, the 52-week high was $39.98.

Biggest Losers

Shares of Galena Biopharma, Inc. (NASDAQ: GALE) are down 17.38% to $1.55 on trading volume of 10.5 million shares.  The company plans to offer 15.16 shares of common stock to the public for $1.60. The 52-week low is 36 cents.

Shares of GT Technologies Inc. (NASDAQ: GTAT) are down 12.14% to $3.04 on trading volume of 6.2 million. The company, which manufactures solar and LED equipment,  announced it would likely take a loss in the fourth quarter as customers struggle to access new capital.  The 52-week low is $3.00

Shares of Smith & Wesson Holding Corporation (NASDAQ: SWHC) are down 9.17% to $7.86 on trading volume of 8.8 million. Investors have been selling shares over concern that new gun regulations will be enacted following the shooting in Newton, Conn. on Friday. The 52-week low is $3.83.

Samuel Weigley

Follow him on Twitter: SWeigley