Companies /Healthcare

Spruce Biosciences Inc

NASDAQ: SPRB Biotechnology

SPRB at a Glance

Valuation
Market cap
$112.0M
Profitability
Revenue (TTM)
$697,000
EPS (TTM)
$-37.86
Price
52-week range
$38 – $159
Street target
$148.00
Earnings
Next report
Nov 9, 2026

Headquartered in South San Francisco, CA Fiscal year ends December NASDAQ: SPRB sprucebio.com

About Spruce Biosciences

Spruce Biosciences is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need. The company's lead product candidate is tralesinidase alfa enzyme replacement therapy (TA-ERT), which is in late-stage development for the treatment of mucopolysaccharidoses type IIIB (MPS IIIB), also known as Sanfilippo Syndrome Type B, a devastating pediatric neurodegenerative disorder with no FDA-approved therapies. TA-ERT is administered intracerebroventricularly and has received Breakthrough Therapy Designation, Rare Pediatric Disease Designation, Fast Track Designation, and Orphan Drug Designation from the FDA, as well as Orphan Drug Designation in the European Union. The company is pursuing accelerated approval based on a surrogate biomarker endpoint and is planning a BLA submission and confirmatory clinical trial. Spruce is a pre-revenue company currently funding operations through equity financing and strategic investments. Updated

SPRB Coverage

Frequently Asked Questions

What does Spruce Biosciences do?

Spruce Biosciences is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need.

What is the SPRB stock price target?

The Wall Street consensus 12-month price target for SPRB is $148.00.