> Market cap: $401.6 million
> Year-to-date stock price change: +656%
Axim Biotechnologies Inc. (OTCQB: AXIM) is a biotech firm developing cannabidiol-based treatments for pain, spasticity, anxiety and other medical disorders. At one time this year, the stock was up 2,000% on high-hopes for Axim’s product pipeline. Shares closed at $7.77 on Friday, in a 52-week range of $0.21 to $10.00.
> Market cap: $380.1 million
> Year-to-date stock price change: +281%
Medical Marijuana Inc. (OTCPink: MJNA) is a development stage company that develops, sells and distributes hemp oil that contains naturally occurring cannabinoids. The company also licenses its proprietary testing, genetics, labeling and packaging methods for the medicinal herb industry. Shares closed at $0.15 on Friday, and the stock’s 52-week range is $0.03 to $0.27.
> Market cap: $375.5 million
> Year-to-date stock price change: +410%
This clinical-stage pharmaceutical firm is developing a synthetic oral endocannabinoid-mimetic drug, Resunab, for treating chronic inflammation and halting fibrotic processes without causing immunosuppression. Resunab is in Phase 2 clinical testing for treatment of systemic lupus erythematosus. Shares of Corbus Pharmaceuticals Holdings Inc. (NASDAQ: CRBP) closed at $8.55 on Friday, in a 52-week range of $1.01 to $10.78.
> Market cap: $373.6 million
> Year-to-date stock price change: +286%
Aprhia Inc. (OTC: APHQF) also trades on Canada’s venture exchange and is another grower and seller of medical marijuana through retail stores and wholesale distribution. The company recently signed an intellectual property transfer deal with an Arizona medical marijuana grower. Shares closed at $3.537 on Friday. The 52-week range is $0.77 to $5.79.
> Market cap: $340.6 million
> Year-to-date stock price change: -20%
Arena Pharmaceuticals Inc. (NASDAQ: ARNA) is a biopharmaceutical company that developed and distributes a weight-loss drug known as Belviq. Arena makes this list on the strength of a new candidate, ADP371, a cannabinoid-based pain treatment. The stock closed at $1.53 a share on Friday, and its 52-week range is $1.30 to $2.16.
> Market cap: $251 million
> Year-to-date stock price change: -43%
Cara Therapeutics Inc. (NASDAQ: CARA) is a clinical-stage biopharma firm that is developing and commercializing treatments for pain and pruritus. In addition to a pre-clinical cannabinoid candidate, CR701, the company has a pain treatment in late-stage trials. Shares closed at $9.97 on Friday. The 52-week range is $4.26 to $17.69.
One company not included in this list is Scotts Miracle-Gro Co. (NYSE: SMG). The company’s $5.76 billion market cap would put it at the top of this list, except that so far most of the firm’s activity in the marijuana market has been to acquire hydroponic growers and carving out a space for itself as the leading supplier for indoor growers. Less than 10% of its 2015 revenues of $2.8 billion were due to its hydroponics business.