Here are the five biggest gaining stocks in today’s U.S. markets at closing:

Neutral Tandem Inc. (NASDAQ: IQNT) is up 52% at $4.53.

James River Coal Co. (NASDAQ: JRCC) is up 29.1% at $2.13.

Brightcove Inc. (NASDAQ: BCOV) is up 24.8% at $7.51.

Synacor Inc. (NASDAQ: SYNC) is up 22% at $3.55.

MedicNova Inc. (NASDAQ: MNOV) is up 21.6% at $3.83.

And here are the markets’ five biggest losing stocks today:

SemiLEDS Corp. (NASDAQ: LEDS) is down 20.8% at $1.60.

Regal Beloit Corp. (NYSE: RBC) is down 19.8% at $63.09.

Accelrys Inc. (NASDAQ: ACCL) is down 19% at $7.98.

Kforce Inc. (NASDAQ: KFRC) is down 17.3% at $12.51.

Cray Inc. (NASDAQ: CRAY) is down 17% at $17.56.