34. Ziebach County, South Dakota
> Poverty rate: 42.5%
> Adults with a bachelor’s degree: 16.4%
> Life expectancy at birth: 77.2 years
> Total population: 2,791
> Largest place in county: Eagle Butte
Ziebach County, South Dakota, which lies mostly within the Cheyenne River Indian Reservation, is one of the poorest places in the United States. Nearly 43% of the local population live below the poverty line, the seventh largest share of all U.S. counties and county equivalents. Low incomes, which can make it difficult to access health care and afford healthy lifestyles, are compounded by certain unhealthy behaviors in the county. For example, 32% of local adults smoke and 52% of adults are obese, compared to 17% and 29% of the U.S. adult population, respectively.
As is often the case in low-income areas with large unhealthy populations, Ziebach County has low educational attainment rates. For example, just 16.4% of local adults have a bachelor’s degree, about half the share of adults nationwide.
33. Estill County, Kentucky
> Poverty rate: 30.9%
> Adults with a bachelor’s degree: 9.9%
> Life expectancy at birth: 71.4 years
> Total population: 14,224
> Largest place in county: Irvine
Many of the places with the worst socioeconomic conditions and public health outcomes are in Appalachia, and Estill County, Kentucky, is one of them. Historically, the local economy has centered on coal mining, and as the U.S. energy grid moves away from coal, places like Estill County suffer. Today, nearly 31% of the local population live below the poverty line.
Life expectancy in the county is also nearly eight years below the national average. This is attributable in part to the toll the opioid epidemic is taking on the local population. There are an average of 60 drug overdose deaths for every 100,000 people in the county annually, nearly triple the comparable national rate.

Source: BOB WESTON / Getty Images
32. Humphreys County, Mississippi (sam) done MA f/c
> Poverty rate: 36.4%
> Adults with a bachelor’s degree: 12.8%
> Life expectancy at birth: 74.1 years
> Total population: 8,389
> Largest place in county: Belzoni
Humphreys County, Mississippi, is one of the worst places to live in the United States partially because life expectancy at birth is just 74.1 years — half a decade shy of the national average.
Low life expectancy in Humphreys County is due in part to widespread poverty. Of the nearly 8,400 people living in the area, 36.4% live below the poverty line, more than double the 13.4% national poverty rate. Certain unhealthy behaviors may also be a factor. Adult county residents are far more likely to smoke and be obese, and far less likely to exercise, than they typical American adult.

Source: BOB WESTON / iStock via Getty Images
31. Phillips County, Arkansas
> Poverty rate: 34.5%
> Adults with a bachelor’s degree: 13.8%
> Life expectancy at birth: 71.8 years
> Total population: 18,606
> Largest place in county: West Helena
Phillips County, located in Arkansas’s Delta region where the St. Francis River empties into the Mississippi River, is one of the worst places to live in the United States. A former agricultural and transportation hub, the county has long been in decline. As recently as 1950, over 46,000 people lived in the county. Today, only 18,600 do.
Financial insecurity is high in Phillips County, as 34.5% of local residents live below the poverty line. Limited job availability partially explains the widespread poverty in the county. As of January 2021, 13.8% of the area’s labor force were unemployed. Even before the COVID-19 pandemic, the local 2019 unemployment rate stood at 10.1%, well above the comparable 3.7% national rate.
30. Apache County, Arizona
> Poverty rate: 35.5%
> Adults with a bachelor’s degree: 12.3%
> Life expectancy at birth: 72.9 years
> Total population: 71,511
> Largest place in county: Chinle
Apache County, Arizona, is located in the northeast corner of the state and covers much of the Navajo Nation. Like many counties with large Native American populations, economic opportunity is scarce in Apache County. More than one-third of the population live below the poverty line, more than one in every 10 members of the labor force are unemployed, and more than one in every five households earn less than $10,000 a year.
Such limited economic opportunity and widespread poverty can take a public health toll. In Apache County, life expectancy at birth is only about 73 years — six years shy of the national average.

Source: BOB WESTON / iStock via Getty Images
29. Leflore County, Mississippi
> Poverty rate: 36.8%
> Adults with a bachelor’s degree: 18.5%
> Life expectancy at birth: 70.5 years
> Total population: 29,222
> Largest place in county: Greenwood
Leflore County, Mississippi, is located in the state’s Delta region. Its ranking as one of the worst places to live in the United States is due in large part to relatively poor health outcomes. Life expectancy at birth in the county is just 70.5 years, nearly nine years below the national average. This is partially the result of certain unhealthy behaviors. Adult county residents are far more likely to smoke and be obese, and far less likely to exercise, than they typical American adult.
Many residents are also severely limited in their ability to afford adequate medical care and healthy lifestyles. Leflore County’s poverty rate of 36.8% is among the 20 highest of all U.S. counties and county equivalents.
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