Companies /Healthcare
Relay Therapeutics Inc
NASDAQ: RLAY Biotechnology
$17.06
▼ $0.30 (−1.73%) today
Markets closed · 9:25pm ET

Relay Therapeutics (RLAY) Q4 2025 Earnings

Reported Feb 26, 2026, 4:10pm ET · SEC source
$-0.32
Beat +19.17%
EPS · est. $-0.40
$7.0M
Beat +61.41%
Revenue · est. $4.3M
+2.2%
Beating market
RLAY vs S&P since report
1 quarter
Consecutive EPS misses

How Did RLAY Stock React to Q4 2025 Earnings?

% change · around the report
0+8%+16%+24%Feb 26Feb 27report 4:10pm ETearnings−0.6%+13.0%
0+8%+16%+24%Feb 26Feb 27earnings−0.6%+13.0%
RLAY +13.0%S&P 500 −0.6%
0+8%+16%+24%Feb 26Feb 27report 4:10pm ETearnings−0.4%+13.0%
0+8%+16%+24%Feb 26Feb 27earnings−0.4%+13.0%
RLAY +13.0%NASDAQ −0.4%
0+8%+16%+24%Feb 25Mar 6report 4:10pm ETearnings−2.3%+7.9%
0+8%+16%+24%Feb 25Mar 6earnings−2.3%+7.9%
RLAY +7.9%S&P 500 −2.3%
0+8%+16%+24%Feb 25Mar 6report 4:10pm ETearnings−1.4%+7.9%
0+8%+16%+24%Feb 25Mar 6earnings−1.4%+7.9%
RLAY +7.9%NASDAQ −1.4%
+12.01%
Day of report
−4.58%
Next session
−3.61%
One week
−3.02%
30 days

S&P 500 over the same 30 days: −5.20%.

Did RLAY Beat Earnings? Q4 2025 Results

Yes. Relay Therapeutics reported Q4 2025 earnings of $-0.32 a share on Feb 26, 2026, beating the $-0.40 consensus estimate by 19.2%. Revenue was $7.0M against a $4.3M estimate.

Relay Therapeutics delivered a strong finish to fiscal 2025, beating Wall Street expectations on both the top and bottom lines as its pipeline progress and leaner cost structure took hold. The clinical-stage biotech posted a Q4 loss per share of $0.32, coming in 19.17% better than the consensus estimate of $0.40, while revenue of $7.00 million cleared the $4.34 million analyst forecast by 61.41%, driven largely by recognition of payments under its Exclusive License Agreement with Elevar Therapeutics. The net loss narrowed to $54.89 million from $76.00 million a year earlier, reflecting meaningful cuts to R&D and G&A spending following the company's 2024-2025 research restructuring. Shares surged roughly 19% to a 52-week high in the wake of the report, buoyed further by FDA Breakthrough Therapy designation for lead asset zovegalisib. With $554.52 million in cash and investments on hand, management projects a runway into 2029, and investors are watching closely for Phase 1/2 zovegalisib data at ESMO TAT in March 2026 as the next major catalyst.

Key Takeaways
  • Revenue recognized under Exclusive License Agreement with Elevar Therapeutics for lirafugratinib
  • Reduced R&D and G&A expenses from research organization streamlining in 2024-2025
  • Lower stock compensation expense and employee costs

“Our focus on disciplined execution to date has strengthened the foundation of Relay, aligning our organization to support long-term success. In 2026, Relay is entering a pivotal period defined by multiple upcoming clinical milestones across our zovegalisib program, which recently received Breakthrough Therapy designation from the FDA.”

Relay Therapeutics CEO, on the earnings call

What Was Relay Therapeutics's Outlook in Q4 2025?

Relay Therapeutics expects its current cash, cash equivalents, and investments of approximately $555 million to be sufficient to fund operating expenses and capital expenditure requirements into 2029. Key 2026 milestones include: initial Phase 1/2 data of zovegalisib + fulvestrant at the Phase 3 dose (400mg BID fed) to be presented at ESMO TAT on March 16, 2026; initial Phase 1 clinical data in PIK3CA-driven vascular anomalies planned for 1H 2026 with approximately 20 patients; and breast cancer triplet clinical data along with frontline Phase 3 study design plans anticipated during 2026.

RLAY YoY Financials

Q4 2025 vs Q4 2024 · SEC filings Q4 2024 Q4 2025
$-60,000,000$-40,000,000$-20,000,000$-47,127,866$-60,630,000Operating Income$-42,955,862$-54,889,000Net Income
$-60,000,000$-40,000,000$-20,000,000Operating IncomeNet Income
RLAY income statement, Q4 2025 versus Q4 2024
Metric Q4 2025 Q4 2024 Year over year
Operating Income −$60.6M −$47.1M +28.7%
Net Income −$54.9M −$43.0M +27.8%

Figures from SEC filings and company reports. Not investment advice.