Companies /Healthcare
Zevra Therapeutics Inc
NASDAQ: ZVRA Biotechnology
$11.17
▲ $0.91 (+8.87%) today
Markets closed · 4:49pm ET

Zevra Therapeutics (ZVRA) Q3 2025 Earnings

Reported Nov 5, 2025, 4:08pm ET · SEC source
$-0.01
Beat +50.00%
EPS · est. $-0.02
$26.1M
Miss −2.17%
Revenue · est. $26.6M
−7.5%
Trailing market
ZVRA vs S&P since report
5 quarters
Consecutive EPS beats

How Did ZVRA Stock React to Q3 2025 Earnings?

% change · around the report
−15%−10%−5%0Nov 5Nov 6report 4:08pm ETearnings−0.8%−12.1%
−15%−10%−5%0Nov 5Nov 6earnings−0.8%−12.1%
ZVRA −12.1%S&P 500 −0.8%
−15%−10%−5%0Nov 5Nov 6report 4:08pm ETearnings−1.6%−12.1%
−15%−10%−5%0Nov 5Nov 6earnings−1.6%−12.1%
ZVRA −12.1%NASDAQ −1.6%
−5%0+5%Nov 4Nov 13report 4:08pm ETearnings−0.9%−3.4%
−5%0+5%Nov 4Nov 13earnings−0.9%−3.4%
ZVRA −3.4%S&P 500 −0.9%
−5%0+5%Nov 4Nov 13report 4:08pm ETearnings−2.4%−3.4%
−5%0+5%Nov 4Nov 13earnings−2.4%−3.4%
ZVRA −3.4%NASDAQ −2.4%
−9.73%
Day of report
−3.08%
Next session
+1.54%
One week
−5.61%
30 days

S&P 500 over the same 30 days: +1.90%.

Did ZVRA Beat Earnings? Q3 2025 Results

Yes. Zevra Therapeutics reported Q3 2025 earnings of $-0.01 a share on Nov 5, 2025, beating the $-0.02 consensus estimate by 50.0%. Revenue was $26.1M against a $26.6M estimate.

Zevra Therapeutics posted a mixed but largely encouraging third quarter, nearly reaching breakeven as its rare disease franchise scaled with striking speed. The company reported a loss of just $0.01 per share for Q3 2025, clearing the $0.02 consensus estimate by 50.00%, even as revenue of $26.06 million came in fractionally below the $26.64 million analyst expectation, a miss of 2.17%. The headline figure nonetheless represented a 605.4% surge from the year-ago period, with MIPLYFFA, its treatment for Niemann-Pick disease type C, generating $22.40 million in net revenue as cumulative patient enrollments reached 137 since launch. A $1.20 million Medicare Part D gross-to-net adjustment tempered results modestly, but operating expenses fell to $20.37 million from $27.15 million a year ago, driven by lower R&D spending following the completion of a Phase 2 trial. Analysts trimmed forward estimates following the report, though consensus price targets held steady, suggesting the revenue shortfall was viewed as a near-term rather than structural concern. With $230.40 million in cash and the EMA reviewing arimoclomol for European approval, management expressed confidence in executing its rare disease strategy without tapping capital markets.

Key Takeaways
  • MIPLYFFA commercial ramp with $22.4 million in Q3 net revenue
  • 137 cumulative prescription enrollment forms for MIPLYFFA since launch
  • Market access reaching 66% of covered lives for MIPLYFFA
  • Significant R&D expense reduction of $7.5 million year-over-year following KP1077 Phase 2 trial completion
  • Operating expenses declined from $27.2 million to $20.4 million year-over-year

“Zevra is well-positioned for continued growth, driven by the strong performance of MIPLYFFA and the meaningful impact we are delivering to patients with Niemann-Pick disease type C.”

Zevra Therapeutics CEO, on the earnings call

What Was Zevra Therapeutics's Outlook in Q3 2025?

The company believes its available financial resources, including cash, cash equivalents, and securities of $230.4 million, are sufficient to execute on its strategic priorities independent from the capital markets. Zevra expects continued growth driven by the ongoing commercial ramp of MIPLYFFA. The company has scaled back sales and marketing for OLPRUVA while evaluating future options for that product. A Marketing Authorisation Application for arimoclomol is under review by the EMA for potential European expansion.

ZVRA YoY Financials

Q3 2025 vs Q3 2024 · SEC filings Q3 2024 Q3 2025
$0$8.0M$16.0M$24.0M$3.7M$26.1MRevenue$1.9M$4.1MOperating Income$-274,249$-544,000Net Income
$0$8.0M$16.0M$24.0MRevenueOperating IncomeNet Income
ZVRA income statement, Q3 2025 versus Q3 2024
Metric Q3 2025 Q3 2024 Year over year
Revenue $26.1M $3.7M +605.4%
Operating Income $4.1M $1.9M +115.2%
Net Income −$544,000 −$274,249 +98.4%

ZVRA Revenue by Segment

MIPLYFFA$22.4M
Expanded Access Program$2.4M
French EAP Arimoclomol Reimbursements
French EAP for arimoclomol
AZSTARYS License Agreement$1.2M
AZSTARYS Royalties and Reimbursements
AZSTARYS royalties and reimbursements
OLPRUVA$100,000

Figures from SEC filings and company reports. Not investment advice.