CBOE Holdings Inc. (NASDAQ: CBOE) was downgraded to Underperform from Outperform at CLSA.

CME Group Inc. (NASDAQ: CME) was maintained as Underperform but the price target was raised to $63 from $83 (versus an $88.55 close) at RBC Capital Markets.

Acadia Pharmaceuticals Inc. (NASDAQ: ACAD) was started as Buy with a $40 price objective (versus a $19.36 close) at Bank of America Merrill Lynch.

Amedisys Inc. (NASDAQ: AMED) was raised to Outperform with a $40 price target at Oppenheimer.

Antero Midstream Partners L.P. (NYSE: AM) was downgraded to Neutral From Outperform at R.W. Baird.

AstraZeneca PLC (NYSE: AZN) was downgraded to Hold from Buy at HSBC.

Big 5 Sporting Goods Corp. (NASDAQ: BGFV) was raised to Buy from Hold at Stifel.

DexCom Inc. (NASDAQ: DXCM) was downgraded to Neutral from Overweight and the price target was cut to $47 from $100 (versus a $61.98 close, after a 12.2% drop) at R.W. Baird.

Energy Transfer Partners L.P. (NYSE: ETP) was downgraded to Neutral from Outperform by R.W. Baird.

Energy Transfer Equity L.P. (NYSE: ETE) was downgraded to Neutral from Outperform at R.W. Baird.

Enlink Midstream LLC (NYSE: ENLC) was downgraded to Underperform at R.W. Baird.

EPAM Systems Inc. (NYSE: EPAM) was raised to Buy from Neutral at Monness Crespi Hardt.

HSBC Holdings PLC (NYSE: HSBC) was downgraded to Underweight from Equal Weight at Morgan Stanley.

Nektar Therapeutics (NASDAQ: NKTR) was reiterated as Buy with a fair value of $21 at Janney Capital Markets.

Novo Nordisk A/S (NYSE: NVO) was downgraded to Sell from Neutral at UBS.

ONEOK Inc. (NYSE: OKE) was downgraded to Neutral from Outperform at R.W. Baird.

ONEOK Partners L.P. (NYSE: OKS) was downgraded to Underperform at R.W. Baird.

Spectra Energy Corp. (NYSE: SE) was started as Hold at Deutsche Bank.

Supernus Pharmaceuticals Inc. (NASDAQ: SUPN) was raised to Buy from Hold with a $18 price target (versus a $12.13 close) at Jefferies.

Tallgrass Energy G.P. (NYSE: TEGP) was downgraded to Neutral from Outperform at R.W. Baird.

WisdomTree Investments Inc. (NASDAQ: WETF) was downgraded to Underperform from Market Perform at Keefe Bruyette & Woods.

If you missed Friday’s top analyst upgrades and downgrades, they included Coca-Cola, Goldman Sachs, JPMorgan, LinkedIn, Linn Energy, Tableau Software, Weatherford International and over a dozen more companies.