26. You Will Meet a Tall Dark Stranger (2010)
> Fellow leads: Naomi Watts, Josh Brolin, Gemma Jones
> Director: Woody Allen
> Domestic box office: $3.25 million
This time, Hopkins plays a divorcé who makes some regrettable decisions and hopes to win his ex-wife back.
25. The Human Stain (2003)
> Fellow leads: Nicole Kidman, Ed Harris, Gary Sinise
> Director: Robert Benton
> Domestic box office: $5.38 million
Hopkins plays a disgraced college professor who has been living with a close-kept secret for most of his life.
24. Instinct (1999)
> Fellow leads: Cuba Gooding Jr., Donald Sutherland, Maura Tierney
> Director: Jon Turteltaub
> Domestic box office: $34.11 million
This psychological drama delves into the mind of an anthropologist, played by Hopkins, who is convicted of murdering two park rangers while living with mountain gorillas in Uganda.
23. Noah (2014)
> Fellow leads: Russell Crowe, Jennifer Connelly, Emma Watson
> Director: Darren Aronofsky
> Domestic box office: $101.20 million
Hopkins plays Methuselah, Noah’s grandfather, who gives Noah a seed from the Garden of Eden, from which a forest will grow overnight.
22. Hannibal (2001)
> Fellow leads: Julianne Moore, Gary Oldman, Ray Liotta
> Director: Ridley Scott
> Domestic box office: $165.09 million
In his second turn as Dr. Hannibal Lecter, Hopkins’ character is on the run from the authorities and a surviving victim ten years after the events that took place in “The Silence of the Lambs.”