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25. Salem, Oregon
> Overall score: 49.28/100
> Affordability rank: 42nd out of 50
> Economic well-being rank: 6th out of 50
> Education and health rank: 21st out of 50
> Quality of life rank: 28th out of 50
> Population: 169,259
> Median household income: $55,920
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24. Columbia, South Carolina
> Overall score: 49.33/100
> Affordability rank: 25th out of 50
> Economic well-being rank: 41st out of 50
> Education and health rank: 29th out of 50
> Quality of life rank: 16th out of 50
> Population: 133,273
> Median household income: $47,286
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23. Boston, Massachusetts
> Overall score: 49.79/100
> Affordability rank: 49th out of 50
> Economic well-being rank: 18th out of 50
> Education and health rank: 4th out of 50
> Quality of life rank: 1st out of 50
> Population: 684,379
> Median household income: $71,115
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22. Cheyenne, Wyoming
> Overall score: 49.80/100
> Affordability rank: 5th out of 50
> Economic well-being rank: 23rd out of 50
> Education and health rank: 37th out of 50
> Quality of life rank: 43rd out of 50
> Population: 63,607
> Median household income: $64,598
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21. Phoenix, Arizona
> Overall score: 50.81/100
> Affordability rank: 32nd out of 50
> Economic well-being rank: 3rd out of 50
> Education and health rank: 33rd out of 50
> Quality of life rank: 26th out of 50
> Population: 1,633,017
> Median household income: $57,459
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