Altimmune is a late clinical-stage biopharmaceutical company focused on developing therapies for patients with serious liver diseases. Its lead candidate, pemvidutide, is a novel peptide dual receptor agonist with balanced 1:1 glucagon/GLP-1 activity designed to reduce liver fat, inflammation, and fibrosis. Pemvidutide is being developed for three indications: metabolic dysfunction-associated steatohepatitis (MASH), alcohol use disorder (AUD), and alcohol-associated liver disease (ALD). The glucagon receptor activation provides direct liver effects, while GLP-1 receptor activation mediates metabolic effects including appetite suppression, weight loss, and pathways related to craving and reward. The company has received FDA Breakthrough Therapy Designation for MASH and Fast Track designations for both MASH and AUD. Altimmune trades on the Nasdaq under the ticker ALT and is currently pre-revenue, funding operations through equity offerings and debt financing. Updated
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Altimmune is a late clinical-stage biopharmaceutical company focused on developing therapies for patients with serious liver diseases. Its lead candidate, pemvidutide, is a novel peptide dual receptor agonist with balanced 1:1 glucagon/GLP-1 activity designed to reduce liver fat, inflammation, and fibrosis.