Natera Inc
Q1 2025 Earnings
Market Reaction
S&P 500 over the same 30 days: +6.56%.
Did NTRA Beat Earnings? Q1 2025 Results
Natera posted a convincing beat across both earnings and revenue in the first quarter of 2025, reporting a net loss of $0.50 per share against analyst expectations closer to a $0.59 loss, while revenue climbed 36.5% year-over-year to $501.83 million, well ahead of the roughly $460.85 million consensus. The primary engine behind that top-line strength was broad-based volume growth and average selling price improvements, with total tests processed rising 16.2% to approximately 855,100, led by a 46.1% surge in oncology testing to roughly 167,700 units. Gross margin expanded meaningfully to 63.1% from 56.7% a year ago, reflecting cost discipline and favorable cash collections on prior-period tests. Operating losses widened modestly to $79.18 million as R&D and SG&A spending accelerated to support new products and clinical trials. The company generated $44.50 million in operating cash flow and ended the quarter with approximately $991.60 million in cash and investments. Encouraged by the momentum, Natera raised its full-year 2025 revenue guidance to $1.94 billion to $2.02 billion, representing approximately 26% pro-forma growth, while maintaining gross margin guidance of 60% to 64%.
- Total test volume growth of 16.2% YoY to approximately 855,100 tests
- Oncology test volume growth of 46.1% YoY to approximately 167,700 tests
- Clinical oncology units grew ~16,500 sequentially from Q4 2024, a record sequential quarter growth
- Average selling price improvements
- Cash collections exceeding initial revenue estimates driving true-ups
- Continued progress in reducing cost of revenues per test
- Strong performance across all product areas: women's health, organ health, and oncology
“We delivered another strong quarter, with volume growth across the business, including a record growth quarter for Signatera. Our progress reflects the strength of our technology and the breadth and quality of the clinical data. With multiple high-impact datasets reading out and trials underway, we believe we're in a strong position to help millions of patients in the future.”
Natera CEO, on the earnings call
Forward Guidance & Outlook
Natera raised its 2025 full-year revenue guidance to $1.94 billion–$2.02 billion, up from a prior range of $1.87 billion–$1.95 billion, representing pro-forma revenue growth of approximately 26%. Gross margin guidance is maintained at 60%–64%. SG&A costs are now expected to be $975 million–$1.05 billion (up from $950 million–$975 million), reflecting commercial investments and incremental non-cash/non-recurring charges. R&D costs are guided to $550 million–$590 million (up from $525 million–$550 million) as clinical trials and product investments accelerate. The company expects positive net cash flow for the full year 2025.
NTRA YoY Financials
NTRA Revenue by Segment
Figures from SEC filings and company reports. Not investment advice.