Health and Healthcare
Alder Biopharma Soars on Positive Mid-Stage Trial Results
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Alder Biopharmaceuticals Inc. (NASDAQ: ALDR) led the bulls on Monday morning following the release of its mid-stage clinical trial results. The company announced positive top-line data from two clinical trials evaluating ALD403. Just earlier this month, 24/7 Wall St. pointed out that this was one of the stocks to watch with an upcoming FDA decision.
For some background, ALD403 is Alder’s proprietary monoclonal antibody product candidate for migraine prevention that targets calcitonin gene-related peptide.
Positive top-line data from a Phase 2b study of patients with chronic migraine demonstrated that ALD403 acted rapidly and prevented migraine over the entire 12-week study period, meeting both primary and secondary efficacy endpoints. Additionally, positive Phase 1 study data demonstrated that the pharmacokinetics and pharmacodynamics by intravenous, subcutaneous or intramuscular injection of ALD403 support a quarterly single injection dosing strategy.
The 300 mg and 100 mg dose levels of ALD403 met the primary efficacy endpoint of the study, a 75% reduction in migraine days over the entire 12 weeks in 33% and 31% of patients, respectively.
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