Source: Sean Pavone / iStock via Getty Images
40. Pittsburgh, PA
> Annual drug deaths, 2019-2021: 47.4 per 100,000 residents
> Total drug deaths, 2019-2021: 3,307
> Poverty rate: 11.2%
> Population: 2,353,538
39. Kokomo, IN
> Annual drug deaths, 2019-2021: 47.4 per 100,000 residents
> Total drug deaths, 2019-2021: 118
> Poverty rate: 10.6%
> Population: 83,687
Source: Sean Pavone / iStock via Getty Images
38. Philadelphia-Camden-Wilmington, PA-NJ-DE-MD
> Annual drug deaths, 2019-2021: 47.4 per 100,000 residents
> Total drug deaths, 2019-2021: 8,742
> Poverty rate: 12.3%
> Population: 6,228,601
Source: espiegle / iStock via Getty Images
37. Columbus, OH
> Annual drug deaths, 2019-2021: 47.5 per 100,000 residents
> Total drug deaths, 2019-2021: 3,047
> Poverty rate: 12.2%
> Population: 2,151,017
Source: csfotoimages / iStock Editorial via Getty Images
36. Homosassa Springs, FL
> Annual drug deaths, 2019-2021: 47.5 per 100,000 residents
> Total drug deaths, 2019-2021: 219
> Poverty rate: 16.1%
> Population: 158,083
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