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25. Lexington-Fayette, KY
> Annual drug deaths, 2019-2021: 51.4 per 100,000 residents
> Total drug deaths, 2019-2021: 799
> Poverty rate: 13.2%
> Population: 517,846
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24. Scranton-Wilkes-Barre, PA
> Annual drug deaths, 2019-2021: 51.5 per 100,000 residents
> Total drug deaths, 2019-2021: 862
> Poverty rate: 13.1%
> Population: 567,750
24/7 Wall St.
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23. Parkersburg-Vienna, WV
> Annual drug deaths, 2019-2021: 52.5 per 100,000 residents
> Total drug deaths, 2019-2021: 140
> Poverty rate: 13.9%
> Population: 88,181
22. Springfield, OH
> Annual drug deaths, 2019-2021: 52.6 per 100,000 residents
> Total drug deaths, 2019-2021: 212
> Poverty rate: 16.3%
> Population: 135,633
Source: DenisTangneyJr / iStock via Getty Images
21. Pittsfield, MA
> Annual drug deaths, 2019-2021: 52.6 per 100,000 residents
> Total drug deaths, 2019-2021: 199
> Poverty rate: 9.8%
> Population: 128,657
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