21. Massachusetts: Boston
> Population, 2017: 685,094
> Change since 2010: +10.4%
> State population: 6,859,819 (15th highest)
> Share of state pop. living in largest city: 10.0% (25th lowest)
> Land area: 89.6 sq. miles
> Population density: 12,793 / sq. mile
22. Michigan: Detroit
> Population, 2017: 673,104
> Change since 2010: -5.3%
> State population: 9,962,311 (10th highest)
> Share of state pop. living in largest city: 6.8% (13th lowest)
> Land area: 142.9 sq. miles
> Population density: 5,144 / sq. mile
23. Minnesota: Minneapolis
> Population, 2017: 422,331
> Change since 2010: +10.2%
> State population: 5,576,606 (22nd highest)
> Share of state pop. living in largest city: 7.6% (18th lowest)
> Land area: 57.5 sq. miles
> Population density: 7,088 / sq. mile
24. Mississippi: Jackson
> Population, 2017: 166,965
> Change since 2010: -3.9%
> State population: 2,984,100 (17th lowest)
> Share of state pop. living in largest city: 5.6% (10th lowest)
> Land area: 113.2 sq. miles
> Population density: 1,563 / sq. mile
25. Missouri: Kansas City
> Population, 2017: 488,943
> Change since 2010: +6.1%
> State population: 6,113,532 (18th highest)
> Share of state pop. living in largest city: 8.0% (19th lowest)
> Land area: 319.0 sq. miles
> Population density: 1,460 / sq. mile
