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15. New Bern, NC
> Annual drug deaths, 2019-2021: 56.8 per 100,000 residents
> Total drug deaths, 2019-2021: 194
> Poverty rate: 11.7%
> Population: 120,508
Source: benedek / iStock via Getty Images
14. Palm Bay-Melbourne-Titusville, FL
> Annual drug deaths, 2019-2021: 56.9 per 100,000 residents
> Total drug deaths, 2019-2021: 1,040
> Poverty rate: 11.1%
> Population: 616,628
24/7 Wall St.
Source: Roberto Galan / iStock Editorial via Getty Images
13. Muncie, IN
> Annual drug deaths, 2019-2021: 57.1 per 100,000 residents
> Total drug deaths, 2019-2021: 194
> Poverty rate: 18.1%
> Population: 111,871
Source: StanRohrer / iStock via Getty Images
12. Youngstown-Warren-Boardman, OH-PA
> Annual drug deaths, 2019-2021: 57.8 per 100,000 residents
> Total drug deaths, 2019-2021: 928
> Poverty rate: 16.6%
> Population: 538,069
Source: WilliamSherman / iStock via Getty Images
11. Johnstown, PA
> Annual drug deaths, 2019-2021: 58.3 per 100,000 residents
> Total drug deaths, 2019-2021: 228
> Poverty rate: 12.6%
> Population: 132,167
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