Headquartered in Cambridge, MA·Fiscal year ends December·NASDAQ: NTLA·intelliatx.com
About Intellia Therapeutics
Intellia Therapeutics is a clinical-stage biopharmaceutical company developing in vivo CRISPR gene editing therapies intended as one-time, potentially curative treatments for severe diseases. Its lead candidate, lonvoguran ziclumeran (lonvo-z), is designed to inactivate the KLKB1 gene to permanently lower kallikrein and bradykinin levels in hereditary angioedema (HAE). The FDA has accepted the lonvo-z BLA under Priority Review with a PDUFA date of March 10, 2027, and the company is preparing a U.S. commercial launch in the first quarter of 2027. Its second late-stage candidate, nexiguran ziclumeran (nex-z), is designed to inactivate the TTR gene in the liver to treat transthyretin (ATTR) amyloidosis. Nex-z is in the MAGNITUDE (ATTR-CM) and MAGNITUDE-2 (ATTRv-PN) Phase 3 trials, with Intellia leading development and commercialization in collaboration with Regeneron. The company currently earns revenue only from collaborations, chiefly with Regeneron. It funds operations from cash reserves and a term loan facility of up to $400 million with OrbiMed. Updated
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Intellia Therapeutics is a clinical-stage biopharmaceutical company developing in vivo CRISPR gene editing therapies intended as one-time, potentially curative treatments for severe diseases.