Eli Lilly, Novo Nordisk and Merck: Buy, Sell or Hold?
Lilly, Novo, and Merck have each priced in a radically different version of the next two years, and one of them looks like a setup where the market has it badly wrong.
Among the pharma names investors debate most, Eli Lilly (NYSE:LLY | LLY Price Prediction) at $1,216.46 screens most constructively, Novo Nordisk (NYSE:NVO) at $45.92 looks range-bound, and Merck (NYSE:MRK) at $135.97 screens as fairly valued. All three trade in a market obsessed with GLP-1 economics and Merck’s KEYTRUDA patent cliff, and each has priced in a very different version of the future.
The scoreboard already tells a story. Lilly is up 10.63% year to date, Merck has ripped 31.09%, and Novo has slipped 7.57%, versus an S&P 500 gain in the high single digits. Who is winning the incretin war and who is stuck defending share is largely settled at these prices.
Eli Lilly: Why the GLP-1 Leader Still Has the Strongest Setup
Lilly’s Q2 delivered $14.9 billion in combined Mounjaro and Zepbound revenue, non-GAAP EPS of $8.38, and total revenue growth of 48%. Management raised 2026 guidance to $85 to $87 billion in revenue and $35.50 to $36.50 in EPS.
Foundeo, the oral GLP-1, has scaled from 8,000 to 36,000 prescribers, and Retratrutide’s TRIUMPH readouts set up a Q1 2027 BLA that CEO Dave Ricks says gives Lilly “a pretty large lead over any competitors with a triple acting medicine.”
The mean analyst target sits at $1,310.90 across 28 analysts, with 22 Buy or Strong Buy ratings. A forward P/E of 32x is not cheap, yet quarterly revenue growth of 47.7% and gross margin of 86.3% give the multiple room.
Targets are a data point, not a promise, but at $1,216 manufacturing capacity and price realization are the main things to watch while demand keeps compounding.
Novo Nordisk: Priced for Bad News While Recovery Remains Distant
Novo’s Q2 landed adjusted sales of DKK 78.5 billion with CER operating profit growth of 11%, and Wegovy pill has cleared 5 million prescriptions with roughly 90% of the oral obesity market. Valuation looks arresting at a forward P/E of 14x with a 4% dividend yield.
The bear case is loud. Full-year 2026 guidance still calls for 0% to -6% sales growth at CER, the SUSE cardiovascular trial for siltivecumab failed with a MACE hazard ratio of 0.99, monlunabant absorbed a $4 billion impairment, and list price cuts of roughly 50% on Wegovy and 35% on Ozempic take effect January 1, 2027.
A mean target of $47.03 across 14 analysts, of which 10 rate Hold, implies almost no upside from here. Patience wins until pricing bottoms and Cagrisema’s Redefine 11 data clears.
Merck: KEYTRUDA Cliff Priced In, Pipeline Still Ahead
Merck’s YTD rally reflects renewed confidence in CEO Rob Davis’s pitch that the KEYTRUDA loss of exclusivity is “more of a hill than a cliff.” Q2 KEYTRUDA franchise sales of $8.4 billion grew 4%, WINREVAIR hit $588 million up 75%, and Davis’s $70 billion new-product framework is de-risking faster than expected on positive SAC-TMT and Tulasocobar readouts.
Shares now sit right at the $137.73 mean target across 28 analysts. Forward P/E of 50x reflects a depressed EPS base from a $2.31 per share Terns charge inside 2026 guidance of $2.66 to $2.76.
With Lipvendra, the first oral PCSK9, launching and IDXD approval expected in the second half, the setup is constructive, but the easy money after a 31.09% YTD move has been made.
The Bottom Line at Today’s Prices
At $1,216.46, Lilly screens most attractively on incretin dominance and a Retratrutide catalyst Wall Street has not fully valued. Novo looks range-bound at $45.92 until pricing stabilizes and pipeline setbacks stop compounding. At $135.97, Merck trades near fair value after a strong run, with the 2027 catalyst calendar deciding the next leg.
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Vandita Jadeja is a financial publisher with over a decade of experience writing about financial topics, including investment, savings, retirement, insurance and banking. Vandita is a Chartered Accountant who loves to debunk financial concepts for readers.
Her work has appeared on sites that include The Motley Fool, InvestorPlace, and Benzinga. She covers investing and focuses on stock picks and price prediction for 24/7 Wall St.
When not looking for the next stock investment opportunity, she can be found traveling, reading, chasing sunsets and enjoying her iced latte.
