Astex Pharmaceuticals, Inc. (NASDAQ: ASTX) is the NASDAQ pre-market leader this morning on news that its subcutaneous SGI-110 interim phase I.II MDS and AML data demonstrated differentiated PK profile and good tolerability, as well as a preliminary promising complete responses in heavily pre-treated acute myelogenous leukemia patients enrolled in the Phase 1 segment of the trial.
The randomized Phase 1/2 first-in-human dose escalation study had 66 patients enrolled who were previously treated as of March 28, 2012.
In the data, two of the seven evaluable refractory AML patients with adequate hypomethylation with no prior resistance to hypomethylating agents showed a complete response and one patient showed partial response.
The pharmacokinetic data suggests delivery of decitabine by SGI-110 achieves high decitabine exposure. It also showed a longer half life and a potent dose-dependent hypomethylation induction in the daily regimen.
Shares are trading higher by 13.6% at $2.09 in the pre-market and the 52-week trading range is $1.51 to $3.35. The market cap before the news was a mere $171 million.
JON C. OGG
Essential Tips for Investing: Sponsored
A financial advisor can help you understand the advantages and disadvantages of investment properties. Finding a qualified financial advisor doesn’t have to be hard. SmartAsset’s free tool matches you with up to three financial advisors who serve your area, and you can interview your advisor matches at no cost to decide which one is right for you. If you’re ready to find an advisor who can help you achieve your financial goals, get started now.
Investing in real estate can diversify your portfolio. But expanding your horizons may add additional costs. If you’re an investor looking to minimize expenses, consider checking out online brokerages. They often offer low investment fees, helping you maximize your profit.
Thank you for reading! Have some feedback for us?
Contact the 24/7 Wall St. editorial team.
Editors' Picks
