The underwriters for the offering are Leerink Partners, RBC Capital, Needham and Wedbush.
This is a clinical stage biopharmaceutical company engaged in the research and development of novel anti-infective agents to treat serious infections, with a focus on the pleuromutilin class of antibiotics. The company is developing its lead product candidate, lefamulin, to be the first pleuromutilin antibiotic available for systemic administration in humans. Nabriva is developing both intravenous (IV) and oral formulations of lefamulin for the treatment of community-acquired bacterial pneumonia (CABP) and intends to develop lefamulin for additional indications other than pneumonia.
Nabriva has completed a phase 2 clinical trial of lefamulin for acute bacterial skin and skin structure infections (ABSSSI). Based on the clinical results of lefamulin for ABSSSI, as well as its rapid tissue distribution, including substantial penetration into lung tissue and fluids, the company is preparing to initiate two international, pivotal phase 3 clinical trials of lefamulin for the treatment of moderate to severe CABP. These will be the first clinical trials the company has conducted with lefamulin for the treatment of CABP.
The company plans to initiate the first of these trials in the fall of 2015 and the second trial in the first half of 2016. Based on the expectations regarding initiation of these trials and estimates regarding patient enrollment, top-line data available for both trials is expected in late 2017. If the results of these trials are favorable, including achievement of the primary efficacy endpoints of the trials, Nabriva expects to submit applications for marketing approval for lefamulin for the treatment of CABP in both the U.S. and Europe in 2018.
The company expects to use the net proceeds from this offering to fund the clinical development of lefamulin, repay its indebtedness, and for general corporate purposes.
Sponsored: Tips for Investing
A financial advisor can help you understand the advantages and disadvantages of investment properties. Finding a qualified financial advisor doesn’t have to be hard. SmartAsset’s free tool matches you with up to three financial advisors who serve your area, and you can interview your advisor matches at no cost to decide which one is right for you. If you’re ready to find an advisor who can help you achieve your financial goals, get started now.
Investing in real estate can diversify your portfolio. But expanding your horizons may add additional costs. If you’re an investor looking to minimize expenses, consider checking out online brokerages. They often offer low investment fees, helping you maximize your profit.