10 Large-Cap Stocks Up 1000% to 4000% Over the Past Decade

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Align Technology
> Up Over 1,400%

Align Technology Inc. (NASDAQ: ALGN) is now worth almost $22 billion, and it has Invisalign and other dental/aesthetic offerings to thank for its success. At $275.72 a share, it is down from a 52-week high of $334.64, and its all-time high in 2018 was almost $400. Shares closed out 2009 at $17.82.

Regeneron Pharmaceuticals
> Up over 1,400%

At $372.26 most recently and with more than a $40 billion market cap, its price on the last day of 2009 was $24.18 a share. Its 52-week high of $442.00 and all-time high above $550 in 2015 would have made for even more impressive gains from trough to peak. This biotech outfit went from an unassuming mid-cap stock to one of the top biotechs by market capitalization. Regeneron Pharmaceuticals Inc. (NASDAQ: REGN) and its developmental or collaboration partners treat issues around the eyes, skin and inflammation.

Ulta Beauty
> Up about 1,400%

Ulta Beauty Inc. (NASDAQ: ULTA) has taken over as the largest salon and beauty related products and services in America and now has more than 1,200 stores. At a time when omnichannel and online offerings have risen, it has thrived. At $262.20 a share with a $15 billion market cap, its 52-week high is actually an even more impressive $368.83. Ulta closed out 2009 at $17.96 on a special dividend-adjusted basis.

Nvidia
> Up over 1,100%

Nvidia Corp. (NASDAQ: NVDA) has gone from graphics and video games into all the hot buzzwords for now and the future: artificial intelligence, machine learning, crypto-mining, super-processors from GPUs, Internet of Things, self-driving cars and so on. At $212.17, with a $130 billion market cap, this stock is down from a 52-week high of $221.41, but it actually peaked earlier in 2018 just above $280. Nvidia’s dividend-adjusted share price was $17.20 on December 31, 2009.

Take-Two Interactive Software
> Up over 1,100%

Take-Two Interactive Software Inc. (NASDAQ: TTWO) closed out 2009 at $10.05, versus $123.73 most recently. The company is still best known for Grand Theft Auto video games and it still does not pay a dividend. The $14 billion market cap is not the largest of the video game makers, and its shares are also down close to 10% from its 2019 high of $135.70, but it was up close to $140 briefly in 2018.

Runners-Up

These runners-up have been involved in acquisitions or have made large changes since 2010.

Broadcom Inc. (NASDAQ: AVGO) is the surviving parent of the Avago and Broadcom merger, which has continued to make acquisitions and returned to a U.S. domicile, and it could have been on the list. The shares were last seen at $316.05, but that was up from a dividend-adjusted price of $15.34 on December 31, 2009.

T-Mobile US Inc. (NASDAQ: TMUS) remains entangled in its multiyear acquisition attempts to bring Sprint Corp. (NYSE: S) into its grasp, and it would be just short of the ten-bagger category, without wondering if its shares could have kept climbing without the distraction of a large and contested merger.

Advanced Micro Devices Inc. (NASDAQ: AMD) is up about 20-fold from under $2 in mid-2015, but its longstanding history of ups and downs dates back more than 30 years, and it was closer to $8 during the time-frame used for this reference.

Facebook Inc. (NASDAQ: FB) is up about 11 times its absolute lows of closer to $18, but that was after a major fall after its IPO, and it was not even public at the start of 2010.

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